Steroids Induced Hyperglycemia: Its Effects and Management

Steroids are medications that have been widely utilized for a number of ailments, both acute and chronic. The action endogenous steroids, nuclear hormones penetrate cell membranes to bind certain glucocorticoid receptors in the cytoplasm target cells form glucocorticoid-receptor (GR) complexes, is mimicked by synthetic glucocorticoids. translocated activated GR complex regulates DNA transcription nucleus. main factor drug-induced hyperglycemia steroids. They not only worsen those who already diabetes mellitus (DM), but they can also lead DM people who've previously experienced it. Their incidence reach up 46% patients, their glucose levels rise 68% over baseline. Steroid effects often narrow reversible. Drug-induced supposed go away as steroid doses decreased because impact on endocrine metabolism returns normal; however, this case. synthesis lipolysis, proteolysis, hepatic increased glucocorticoids (GCs) act substrate oxidative stress metabolism. A wide range medical conditions has treated with GCs. Although steroid-induced proven be medically effective, it still widespread potentially dangerous issue must taken into consideration when administering any GC dose. most common scenario requires use insulin, particularly serum level greater than 200 mg/dL.
 Keywords: Steroids, Glucocorticoids, Hyperglycemia, Resistance, Insulin